VDR is a gene which encodes a protein that acts as a receptor for vitamin D which regulates bone growth and calcium absorption. A variant of the gene, the rs2228570 (FokI polymorphism), is associated with lower bone mineral density in white prepubertal girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the temporal and reciprocal pattern of off- and on- occupancy of the VDRE by the two components, and is affected by chromosomal positions and binding preferences for certain hormones. Microarray studies of human cells indicate that more than 100 genes carry a recognizable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository for data and documents related to legal, business transactions or proceedings that are restricted in viewing printing, downloading, or viewing. It is accessed via a central server as well as an extranet connection which is an Internet connection with restricted access, to provide controlled access to users at specific times when users can access the documents and data.

Investment bankers and companies involved in mergers and acquisitions are among the most frequent users of a VDR. They require a secure platform to share information with potential buyers or investors in a manner that is transparent, and the process of https://www.gescheftmarketing.de/2021/12/29/gaining-knowledge-and-business-direction-2/ due diligence can require huge amounts of information. Life science companies also use VDRs to keep everything from clinical trials results to HIPAA documentation.