VDRs can be utilized in many ways, however M&A is the most popular. These procedures require a significant quantity of documents to be evaluated and exchanged among the parties involved. Using a VDR permits secure, reliable and fast transfer of these documents.

Members might want to think about introducing an analysis of their VDR to identify trends which could result in incidents at sea. This will allow members to initiate corrective and preventative actions prior to incidents actually happening.

The vitamin D receptor (VDR) is a transcription factor that regulates the expression/transcription of genes (genomic pathways) and the regulation of enzymes (non-genomic pathways). The VDR is primarily found in the nucleus. It binds ligand, typically 1,25-dihydroxyvitamin D3, to specific DNA sequences in the promoter region of target genes and activates or inhibits transcription.

To activate transcription VDR requires a huge multiprotein complex referred to as the mediator complex (DRIP). It has domains similar to the zinc finger DNA binding domain that is found in thyroid hormone receptors, and the 9aaTAD consensus core sequence present in a number of transcription factors. The mediator complex is dominated by a protein dubbed Med220. It interacts with VDR/RXR homodimers stimulated by ligands through one or more LXXLL motif.

A T > C base shift in the FokI mutagenicity of VDR removes the translation start site in exon 2. which results in a shorter protein with less binding capacity to DNA and decreased transcriptional activation. This variant has been linked with alterations in calcium absorption, BMD, and gene expression [54].

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